Our Members

Accenture is a global leader in Artificial Intelligence (AI) and Mission Reinvention, employing over 779,000 strategists, technologists, and domain experts across 120+ countries to serve 9,000+ clients in nearly all major industries and core business functions. Accenture Federal Services, our U.S.-based company, brings these capabilities to missions of national importance. With more than 13,000 people and 40+ years of experience supporting the U.S. Government, we deliver technology-driven outcomes while meeting stringent security and compliance requirements. We have been a trusted partner of the U.S. Department of Energy (DOE) and National Laboratories for more than 10 years, Across the scientific sector, our portfolio spans nearly every federal scientific agency, with active partnerships across DOE HQ, NNSA, the national labs, NSF, NOAA, CDC, NIH, USSF, VA, USPTO, DOD, NIST, NASA, and USAF. At DOE, this includes our CBOSS BPA, which continues to drive mission impact at scale.

Accenture is proud to be a member of Genesis Mission Consortium, committed to serving as a solution integrator. In this role, we integrate leading technologies, data, and stakeholders to deliver scalable, cohesive outcomes. Our focus is on providing solutions that scale across DOE, National Laboratories, and the Genesis ecosystem through the following services: program management; platform strategy, onboarding, and optimization; data curation and management; scientific workflow automation; and mission adoption. Accenture is excited to offer a Unified Discovery Platform (currently in Beta) to Genesis partners that brings together leading technology solutions into a single, seamless, secure platform to accelerate scientific research.

Advanced Micro Devices (AMD) is a global leader in high-performance and adaptive computing, delivering the technologies that power the world's most advanced scientific, artificial intelligence, and high-performance computing (HPC) systems. AMD's mission is to build products that accelerate next-generation computing experiences while enabling breakthrough innovation across science, industry, and national priorities.

Within the Genesis Mission Consortium, AMD technologies power many of the world's leading supercomputers and AI systems, providing the computational foundation required to address some of the most complex challenges in energy, materials science, advanced manufacturing, climate research, national security, and scientific discovery. AMD contributes expertise spanning AI infrastructure, exascale computing, scientific computing, advanced processors, accelerators, networking, and open software ecosystems

AMD plays a key role in advancing the Genesis Mission vision of doubling scientific productivity through the development of integrated AI and HPC platforms that connect scientific instruments, data, simulations, foundation models, and autonomous agents into unified discovery workflows. Through collaborations with the Department of Energy, National Laboratories, academia, and industry partners, AMD is helping establish the next generation of AI-enabled scientific infrastructure.

A cornerstone of this effort is Lux, the discovery platform for the Genesis Mission, designed to accelerate the transformation of scientific workflows from instrument to insight. Lux brings together high-performance simulation, AI training and inference, foundation models, agentic systems, and composable computing resources within a sovereign, open, and precision-prioritized architecture optimized for scientific outcomes.

AMD is committed to advancing open science through open-source software, open model ecosystems, transparent evaluation methodologies, and collaborative public-private partnerships. Through its participation in the Genesis Mission Consortium, AMD seeks to help build the computational and AI foundations that will accelerate scientific discovery, strengthen U.S. technology leadership, and enable the next era of American innovation.

Amazon Web Services (AWS) brings substantial resources to support the Genesis Mission through a multi-year $50 billion investment in AI and supercomputing infrastructure, complemented by a $50 million credit initiative for qualifying projects. AWS SMEs and dedicated account teams provide tailored advice and solutions to DOE and NNSA missions.

AWS maintains comprehensive cloud infrastructure across all classification levels, including a certified environment for Secret/Restricted Data (S/RD). With over 200 services spanning commercial, GovCloud, Secret, and Top-Secret environments, AWS has serviced as the Intelligence Community's trusted cloud provider since 2013.

Capabilities span high-performance computing, AI and machine learning platforms, quantum computing, robotics, and IoT infrastructure, supporting end-to-end workflows from data processing through operational deployment. An extensive partner network of over 1,000 companies provides access to pre-vetted solutions, while AWS Marketplace offers streamlined procurement meeting government security standards.

AWS technical teams collaborate directly with DOE through co-innovation partnerships, working alongside scientists and mission specialists to develop solutions and accelerate research-to-deployment timelines. Managed services reduce infrastructure complexity, while comprehensive training programs build workforce expertise. Customer-driven innovation ensures capabilities evolve with Genesis Mission Needs.

Arcee is a U.S.-based AI lab building open, high-performance language models and the tools needed to adapt them for real-world work. We focus on models that are useful, transparent, and practical to deploy in serious environments.

For the Genesis Mission, Arcee will help develop AI models and workflows that support scientific discovery across the national labs. They should help scientists plan experiments, work with complex data, use research tools, and move faster through the scientific process.

Science does not fit into one general-purpose model. Each lab, workflow, and research area has different data, tools, and goals. Arcee will help provide a flexible foundation that allows DOE teams to adapt models for their own needs while keeping control of sensitive data and research systems.

AI tools that can break down tasks, use software, check results, and improve through feedback. This can support scientific reasoning, code modernization, simulation workflows, multimodal data, and "co-scientist" environments where multiple models work together on hard problems.

Our approach emphasizes transparency, evaluation, and access to the pieces needed to understand how models are trained, adapted, and tested. Researchers need confidence in both the model's answers and the processes behind it.

By combining Arcee's open model development with the Genesis Mission's scientific data, facilities, and compute infrastructure, we can help accelerate research, reduce friction for scientists, and support the next generation of American scientific AI.

The Astera Institute is a science and technology philanthropy dedicated to accelerating discovery by experimenting with how research is funded and executed, including new ways of publishing methods, data, and results that do not rely on traditional peer-review platforms. We are fully committed to the principles of open science and the importance of FAIR (Findable, Accessible, Interoperable, and Reusable) scientific outputs.

Within the Genesis Mission Consortium, Astera brings deep expertise in open science infrastructure, AI-ready data systems, and the development of tools and platforms for the rapid publication of usable scientific information. Our open science team is actively building tools, frameworks, and policies that anticipate an AI-native future for science communication.

Astera's contributions to the Genesis Mission are twofold. First, we offer a technical and advisory capacity to help Genesis Mission teams develop automated workflows for data capture, annotation, and deposition alongside open publishing infrastructure already in operation. This provides a concrete path toward addressing the challenges of slow dissemination, poor data standardization, and the absence of machine-readable outputs. Second, Astera is contributing GPU compute credits through pre-purchased capacity on Voltage Park's cloud infrastructure, available to Astera partners for AI model training, inference, and large-scale scientific computing workloads.

Together, these contributions support the Genesis Mission's vision of integrating advanced AI infrastructure and scientific datasets into a coordinated, high-impact discovery engine.

More information coming soon.

More information coming soon.

CoreWeave is the Essential Cloud for AI, a full-stack platform of infrastructure, software, and technical expertise purpose-built for the demands of modern AI. CoreWeave has become one of the fastest-growing cloud platforms in the industry, with nearly a gigawatt of active power across dozens data centers globally and a computing footprint trusted by nine of the top ten AI model providers. The company's platform spans GPU and CPU compute, purpose-built networking, high-throughput storage, and an operating layer for security, observability, and infrastructure management at scale.

Through its participation in the Genesis Mission Consortium, CoreWeave commits to help build the computational and AI infrastructure foundations that will accelerate scientific discovery, strengthen U.S. science, technology and energy innovation, enhance national security, and power American global leadership in AI.

More information coming soon.

Dataerai ("data-array") was founded on a conviction that the next era of discovery and innovation will be defined by how quickly we can turn the world's most complex scientific and engineering data into fuel for AI. From research laboratories to factory floors, the bottleneck for AI-driven progress is no longer computing power or algorithms—it is access to high-quality, AI-ready data.

Dataerai provides the infrastructure that removes this bottleneck. Our platform automatically captures data and rich metadata from instruments, simulations, manufacturing systems, and analysis pipelines at the moment of generation, organizing them into consistent, machine-readable formats with built-in traceability. Designed for distributed environments, the platform allows organizations to keep data securely on-premises or in the cloud while connecting it through a shared layer for search, discovery, and collaboration, all without centralizing or duplicating sensitive data.

Today, much of the data produced by federal investments is used once and never again, making it an enormous untapped national asset. As a member of the Genesis Mission Consortium, Dataerai is working with the Department of Energy to change that. Dataerai contributes expertise in data infrastructure, interoperability, attribution, and provenance to make scientific and engineering data discoverable, accessible, reusable, and AI-ready. We are advancing automated data curation so scientific results are AI-ready from the moment they are created; building the high-throughput data backbones behind digital twins and autonomous laboratories; and developing new ways to track how data assets are used, making visible the full return on America's R&D investments.

Founded by leaders in AI for science, data infrastructure, and national technology policy, Dataerai serves national laboratories, federal agencies, universities, and industry alike to connect the nation's data so that every experiment makes the next one smarter.

Dell Technologies is a trusted infrastructure and innovation partner supporting the Department of Energy’s Mission Genesis Consortium through AI-ready high-performance computing, scalable data infrastructure, and secure platform integration. Dell’s role is to help DOE and its national laboratories operationalize the Genesis vision by connecting advanced compute, data, and AI capabilities that accelerate scientific discovery, strengthen national security research, and advance energy innovation.

Domino Data Lab is a data science “engine” that gives research teams a single, standardized place to develop models, run and track experiments, and deploy AI under governance, instead of stitching those steps together across disconnected tools. Teams can move from a first hypothesis to a system running in production without giving up the security, audit trail, and reproducibility that classified and mission-critical science depend on. Domino also runs on whatever infrastructure an organization already has, from on-premises HPC to cloud and hybrid/multi-cloud, with no vendor lock-in. This flexibility is important for a federated program like the Genesis Mission, which spans DOE's 17 National Laboratories, several agencies, and many private-sector partners. Domino already supports organizations with strict security and regulatory requirements, including major pharmaceutical and life-sciences firms, the U.S. Department of the Navy, and federal agencies. 20 percent of the Fortune 100 run data science development on Domino today.

Dow is one of the world’s leading materials science companies, serving customers in high-growth markets such as packaging, infrastructure, mobility, and consumer applications. Our global breadth, asset integration and scale, customer-focused innovation, and leading business positions enable us to achieve profitable growth and help deliver a sustainable future.

Within the Genesis Mission Consortium, Dow is positioned to serve as an industrial validation and scale-up partner, helping connect AI-enabled discovery workflows with real-world materials, process, and application challenges. Dow can provide access to deep domain expertise and world-class experimental, high-throughput, and pilot-scale capabilities, enabling rigorous validation, scale-up, and translation of AI-enabled solutions into deployable technologies with measurable industrial impact for Genesis partners and the broader U.S. manufacturing ecosystem.

DrivenData helps scientific organizations evaluate and operationalize AI at scale, turning ambitious research goals into measurable AI progress. We are distinguished by our specialization in challenge-driven innovation, AI-ready data infrastructure, and benchmarking and evaluation frameworks that accelerate scientific discovery.

DrivenData brings core capabilities to the Genesis ecosystem: the ability to convert complex scientific problems into AI-ready datasets, rigorous benchmarks and competitive evaluation environments, and collaborative innovation programs. Through our open innovation platform, tooling, and community of 125,000+ data scientists, we help teams to expand and accelerate the generation of reproducible, transparent, and operationally relevant AI for Science.

Since 2014, we have designed and operated more than 150 machine learning challenges and innovation programs, working with NASA, DOE, NIST, NOAA, NIH, CDC, ARPA-H, the Bureau of Reclamation, National Laboratories, and other federal agencies. We currently serve as a NASA prime contractor under the Open Innovation Services (NOIS3) contract and are a founding signatory to the Genesis Mission MOU.

Our work spans scientific domains central to the Genesis Mission. For the Bureau of Reclamation and NASA, we designed and operated the Water Supply Forecast Rodeo, a $500,000 live forecasting competition that advanced probabilistic streamflow prediction across 17 western states. For NASA's Goddard, we led the Mars Spectrometry Challenge, in which more than 1,200 participants submitted 7,800 models that ultimately improved geochemical classification performance by 43 percent for instruments supporting the Curiosity rover mission. We also convened a multi-agency partnership, including NASA, NOAA, EPA, USGS, and others, to develop CyFi, an open-source AI system for detecting harmful algal blooms from satellite imagery.

Through the Genesis Mission, we are committed to helping laboratories, universities, and industry partners create lighthouse challenges, develop AI-ready scientific datasets, evaluate and test AI systems, and accelerate the transition from promising research to deployed scientific capability.

Essential Knowledge Systems (EKS) has developed proprietary AI training software that can be applied to virtually any AI model.

Using Frontier at Oak Ridge National Laboratory and the University of Texas at Austin's Texas Advanced Computing Center (TACC), we have demonstrated the ability to:

- Consistently reduce AI training compute time (including electricity consumption, cloud usage, and token costs) by 5x-10x, while reducing inference costs by up to 2x.

- Reduce training compute time by 24x on Frontier at Oak Ridge National Laboratory by modifying the ORBIT vision transformer model family. This result was unusually high, even by our standards, largely because our training technology is not susceptible to lowered final accuracy somtimes associated with larger training batch sizes. Our technology can train with batches as large as available memory capacity allows while resulting in the maximum accuracy possible.

- Improve model accuracy while increasing efficiency. We have not observed any tradeoffs or sacrifices in performance, and every AI model we have modified has achieved higher accuracy than it was capable of before our enhancements.

HPE is the global leader in supercomputing and AI, bringing powerful capabilities to advancing the development of AI, quantum computing, and next-generation high performance computing (HPC) to drive scientific breakthroughs. Together with the U.S. Department of Energy and its national laboratories, HPE ushered in the world’s first exascale supercomputers for the U.S. and has built upon this innovation and strong public-private partnership to deliver large-scale AI systems as part of Genesis Mission.

HPE is advancing Genesis Mission’s initiatives by building full AI stacks that integrate state-of-the-art accelerators, networking, storage, software and 100% direct liquid cooling. As part of HPE’s involvement, its world-leading services team provides specialized onsite servicing from delivery and deployment, to testing and management, to ensure optimal performance, resilience and security for the systems and the data and AI running on them.

HPE will closely partner with the DOE to support critical R&D to co-design and co-develop future technologies to achieve the national imperative of advancing science and engineering via the Lighthouse Challenges and address next-generation HPC, AI and quantum computing needs.

Since its inception, IBM has been laser focused on developing what’s next in computing. To IBM this always means shooting for the moon. The problems we want to solve aren’t purely academic; they’re not just thought experiments. Modeling financial systems, simulating the properties of new materials, developing more efficient batteries — these are just a few examples of the pressing, real-world problems that IBM, its partners, and businesses, care about. They also present some of the most difficult computations for classical computers to grapple with.

Within Project Genesis, IBM will work on deploying quantum computing systems and solutions that can accelerate research on Genesis problems. IBM will integrate those quantum systems within the Department of Energy’s computational infrastructure, and will develop software, algorithms, and applications that can bring the unprecedented capability of Quantum Computing to address the Genesis Program challenges in fundamentally new ways.

IBM’s approach is firmly in line with what famed physicist Richard Feynman predicted decades before the first quantum computer ever existed. Nature is inherently quantum, and if we want to simulate quantum mechanics, we need to use a quantum computer.

IBM will deploy our research and development expertise in silicon technology, advanced computing, in AI, and most specially in Quantum Computing in support of our work within the Genesis program. In all our Genesis activities, IBM will be pleased to collaborate with the Genesis Consortium and with Genesis partners.

The Illinois Quantum and Microelectronics Park (IQMP) is a first-of-its-kind innovation campus dedicated to accelerating the development, scale-up, and commercialization of quantum technologies and advanced microelectronics. Located in Illinois and anchored by an ecosystem of industry, academia, national laboratories, government partners, manufacturers, suppliers, and end users, IQMP is designed to bridge the gap between research breakthroughs and real-world deployment.

As a member of the Genesis Mission Consortium, IQMP will support technology development, workforce training, supply chain growth, and public-private partnerships across the quantum and advanced computing ecosystem, with a special focus on the intersection of quantum and AI. IQMP brings together stakeholders spanning quantum computing, quantum networking, quantum sensing, microelectronics, high-performance computing (HPC), artificial intelligence, advanced manufacturing, and supporting infrastructure to address critical challenges in technology maturation, integration, and commercialization.

Medra is building the Physical AI Scientist, a closed-loop platform that pairs the AI Experimentalist, a scientific reasoning layer that turns natural-language goals into executable experimental plans, with the Physical AI Lab, a robotics-driven wet-lab execution layer. Together they design, execute, interpret, and improve experiments in a continuous loop, generating structured data and validating model predictions in the real world to provide the infrastructure needed to train and deploy AI in biology at scale.

As a member of the Genesis Mission Consortium, Medra will share access to Medra Labs, including Medra Lab 001, the largest fully-connected autonomous lab for biology in the US, and subject matter expertise to accelerate breakthroughs across the sciences.

Microsoft Corporation is a global technology company whose mission is to empower every person and every organization on the planet to achieve more. Microsoft delivers secure, scalable technologies spanning artificial intelligence, cloud computing, advanced analytics, cybersecurity, developer platforms, and scientific research to help organizations solve complex challenges and accelerate innovation.

Through partnerships with government agencies, national laboratories, universities, and industry, Microsoft supports breakthroughs in science, energy, national security, healthcare, sustainability, and economic development. The company combines world-class research, trusted cloud infrastructure, and advanced AI capabilities to enable collaboration, data-driven discovery, and mission-focused outcomes at scale.

As a Genesis Mission consortium partner, Microsoft contributes expertise in AI-enabled scientific discovery, high-performance computing, cloud infrastructure, cybersecurity, data platforms, and collaborative research. Microsoft works alongside consortium members to accelerate scientific advancement, support multidisciplinary research, and help transform emerging ideas into real-world impact across energy, materials science, biosecurity, quantum science, and other mission-critical domains.

Periodic Labs’ core strength is the integration of deep expertise across three tightly coupled pillars: AI/ML, experimental and computational materials science, and autonomous laboratory operations. Staff from each pillar will be available to collaborate with consortium members and National Labs on Genesis Mission challenges.

Periodic Labs’ platform can bring a unified intelligence layer to DOE-funded scientific projects and National Labs, allowing DOE to retain and organize data under a singular platform, train models on that data, unify their data systems, and unlock DOE-guided agentic capabilities for the scientists and engineers supported by DOE.

More information coming soon.

SambaNova Systems is a full-stack artificial intelligence company delivering the hardware, software, and models that run the largest AI workloads. Built on its purpose-built processors (Reconfigurable Dataflow Unit – RDU), the platform delivers high-throughput, high-concurrency premium inference on air-cooled systems - the efficiency and performance demanded by scientific and national security workloads.

Within the Genesis Mission Consortium, SambaNova’s contribution centers on sovereign, on-premises, open-weight model inference - enabling the DOE National Laboratories and NNSA sites to run state-of-the-art models on controlled and sensitive data without that data ever leaving the facility. As the Genesis Mission works to double scientific productivity with AI by connecting instruments, data, simulations, and foundation models into unified discovery workflows, SambaNova ensures that work can proceed in the most secure environments.

SambaNova brings direct experience deploying production AI inside the DOE complex, with systems in operation across national laboratory environments, accelerating large-model inference alongside traditional HPC. This footprint gives SambaNova firsthand understanding of the security, integration, and mission requirements unique to the laboratory ecosystem.

By combining frontier-model performance with full data sovereignty, SambaNova helps the Genesis Mission deliver secure, AI-enabled discovery at the speed of mission - strengthening U.S. scientific leadership and national security for the next era of American innovation.

Scale AI is the nation's leading provider of AI data, evaluation, and model-readiness infrastructure, supporting both the federal government and the world's leading frontier AI labs in accelerating the reliable deployment of artificial intelligence. Founded in 2016, Scale's mission within the Genesis Mission Consortium is to provide the foundational data and agentic infrastructure that make trustworthy, reproducible AI possible across the Mission's 26 Challenge Areas.

Scale contributes two capabilities that span nearly every Challenge Area. First, high-quality data labeling and curation for computer vision and robotics — the same Data Engine that has produced training data for 90% of the world's leading frontier models, applied to the sensor modalities that power autonomous lab systems for inspection, characterization, and hazardous-environment experimentation. Scale has delivered over 200 million annotations to U.S. government partners with SLA-guaranteed quality metrics exceeding 95% F1. Second, AI agents that interface with existing modeling and simulation infrastructure so scientists can iterate in minutes rather than days. This pattern has already been proven at scale through DIU Thunderforge, where Scale's agents integrated with DoD modeling and simulation tools for military planning.

Scale's infrastructure is deployed across every major classification level and underpins T&E, red-teaming, and post-training work for DoD, IC, and federal partners. Within the Consortium, Scale offers a model-agnostic, traceable, and government-purpose-rights platform ensuring no vendor lock-in and a clear path from unclassified demonstration to classified deployment. Scale is committed to advancing the Genesis Mission's goal of trustworthy, science-grounded AI at national scale.

Schmidt Sciences is a nonprofit organization founded in 2024 by Eric and Wendy Schmidt that works to accelerate scientific knowledge and breakthroughs with the most promising, advanced tools to support a thriving planet. The organization prioritizes research in areas poised for impact including AI and advanced computing, astrophysics, biosciences, climate, and space—as well as supporting researchers in a variety of disciplines through its science systems program.

SeedAI is a nonprofit working to establish AI-readiness for the United States. We run Accelerate Science Now, a coalition of 80+ leading organizations form industry, academia, and civil society, focused on accelerating scientific discovery around the potential of AI. We design policies, programs, and pilots that can accelerate progress and ignite a new era of scientific discovery.

Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning.

Ames National Laboratory integrates materials science, chemistry, condensed matter physics, and computational science to connect discovery with scalable solutions for national priorities in energy, manufacturing, and critical materials.

Ames Laboratory’s decades of leadership in AI/ML tools for accelerated materials discovery are integrated with the Genesis Mission vision for intelligent, high-performance scientific infrastructure, accelerating breakthroughs that translate to real-world impact. Our expertise in materials science and engineering, rare earth science, automated chemistry, and critical materials supports Genesis Mission priorities, particularly those involving critical materials with implications for economic resilience and national security. To reduce foreign supply chain dependence, Ames leverages its leadership in key multi-laboratory efforts, such as the Critical Materials Innovation Hub and the Minerals to Materials Supply Chain Research Facility (METALLIC), and Ames Laboratory’s unique capabilities including the Materials Preparation Center and the Advanced Magnet Facility. Employing the Genesis methodology—coupling human insight with AI-guided discovery—we will rapidly deliver mission-ready alloys, permanent magnets, and composites for national defense and advanced manufacturing, while also focusing on optimizing resource recovery and creating high-performance substitutes.

Ames National Laboratory’s efforts in materials discovery integrates AI/ML, computational approaches, genetic algorithms, and high-performance computing. We are leaders in the development and application of high-performance computational chemistry, and are leveraging quantum computing to predict both chemical and correlated material behavior. Our efforts in Genesis will integrate these developments with AI models to accelerate prediction and synthesis of new molecules and materials with transformative properties, in order to advance biological approaches for critical material recovery, elucidation of catalyst behaviors, performance of alloys in extreme environments, and discovery and understanding of quantum materials that challenge our present understanding.

More information coming soon.

Brookhaven National Laboratory’s nearly 3,000 staff are driven by a common vision: Harnessing AI-accelerated discovery to be the Nation’s leading national lab for scientific breakthroughs that secure America’s future. With seven Nobel Prize-winning discoveries and 79 years of pioneering research, BNL is a multi-program laboratory that brings unique strengths and capabilities to the DOE lab system. The Lab’s science and operations staff work together to implement a bold vision centered on AI-accelerated discovery science, aligned with national priorities and the Genesis Mission. BNL has a key role in advancing DOE’s mission with a focus on U.S. supremacy in discovery science; AI for science and science of AI; quantum information science; onshoring microelectronics; scaling the biotechnology revolution, and securing America’s critical mineral supply. Brookhaven researchers and industry partners will take on key roles in tackling Genesis Mission science and technology challenges related to manufacturing advanced microelectronics, operating and securing the electric grid, and exploring connections between the smallest building blocks of matter and the largest structures in the universe, among other efforts. Brookhaven will provide critical contributions through its DOE Office of Science user facilities, including the National Synchrotron Light Source II, Center for Functional Nanomaterials, and Relativistic Heavy Ion Collider.

Fermilab is America’s particle physics and accelerator laboratory, keeping the nation at the forefront of discovery and innovation. Building on decades of pioneering work in particle physics and accelerator technology, this U.S. Department of Energy national laboratory also drives breakthroughs in artificial intelligence, quantum science, advanced computing, and next generation microelectronics — technologies that power progress in industry, medicine, energy, and national security. Through this combination of scientific depth and technological leadership, Fermilab helps address some of society’s most pressing challenges. The lab is also a hub for innovation, collaboration, and technological advances, bringing together scientists, engineers, and partners.

Fermilab’s contributions to the Genesis Mission build on this foundation of innovation driven by the needs of particle physics, detector development, accelerator science, theory, and quantum information. These frontier challenges have shaped a powerful AI ecosystem that aligns naturally with the goals of the Genesis Mission.

Fermilab’s core AI strengths include intelligent edge sensing through efficient AI and microelectronics co-design enabling nanosecond-to-millisecond decision-making; advanced control and operations powered by surrogate modeling, optimization, and low latency feedback; and robust, interpretable AI grounded in uncertainty quantification and domain adaptation. The lab also operates one of the world’s largest scientific data platforms, efficiently serving more than one exabyte of data per year to global experiments.

By combining these capabilities — extreme environment microelectronics, cutting-edge AI, quantum and advanced computing expertise, and leadership in data-intensive science — Fermilab offers the Genesis Mission a uniquely integrated environment where frontier technologies, extreme-scale data, and high precision scientific instrumentation accelerate discovery and enable transformative new technologies.

Idaho National Laboratory is one of the U.S. Department of Energy's (DOE's) national laboratories. The laboratory performs work in each of DOE's strategic goal areas: energy, national security, science and environment. INL is the nation's leading center for nuclear energy research and development.

Within the Genesis Mission Consortium, INL leads Prometheus — the grand challenge focused on delivering nuclear energy that is faster, safer, and cheaper. Prometheus applies artificial intelligence across the full nuclear reactor lifecycle, from design and licensing through manufacturing, construction, and operations, targeting at least a 2x acceleration in deployment timelines and more than 50% reduction in operational costs.

INL's contributions to the Consortium extend well beyond Prometheus. With a workforce of more than 6,000 experts, INL brings capabilities across advanced energy systems, grid resilience, cybersecurity, digital engineering, and national security — available to support working groups, pilot efforts, and collaborative initiatives across the Consortium. Members have access to unique laboratory facilities and research infrastructure, including test beds, demonstration environments, and specialized user facilities, all governed by standard DOE user agreements.

INL also contributes modeling, simulation, and digital engineering capabilities for system-level analysis and risk-informed decision support, alongside high-performance computing resources and applied AI and machine learning tools operating within secure data environments. These capabilities are complemented by INL's extensive intellectual assets — technologies, software, data, and domain expertise — which INL leverages to advance technology transfer and help move Consortium-relevant innovations toward real-world deployment.

Through advanced computation, network facilities, and data integration, Lawrence Berkeley National Laboratory (Berkeley Lab) is supporting the Department of Energy’s Genesis Mission, a historic national effort to build the world’s most powerful scientific platform to accelerate discovery, strengthen national security, and drive energy innovation. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science.

Lawrence Livermore National Laboratory is supporting the U.S. Department of Energy’s Genesis Mission by building AI-enabled capabilities and leveraging its high-performance computing resources to accelerate design, simulation and manufacturing workflows across national security, fusion energy and advanced materials. Through agentic simulation tools, AI-driven molecular discovery, surrogate modeling and reinforcement learning, LLNL is demonstrating how closed-loop discovery workflows can compress development timelines while maintaining rigorous human oversight in support of deterrence and national security missions. LLNL is also advancing AI-enabled production capabilities, including manufacturing diagnostics, additive manufacturing optimization and AI-based quality control systems that connect design to fabrication. Complementary efforts in federated learning, secure coding assistants and knowledge-graph extraction help strengthen the American Science & Security Platform foundation that Genesis seeks to scale. LLNL is also playing a central role in helping establish the Platform, contributing technical leadership across key pillars including Infrastructure, Models, Data and Partnerships, and enabling secure, unified access to computing resources, scientific data and facilities across the DOE enterprise. Together, these initiatives position LLNL as a key contributor to the Genesis Mission and to building a secure, AI-enabled national discovery infrastructure.

More information coming soon.

The U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL) is dedicated to innovating and accelerating the nation’s energy solutions in hydrocarbons, geothermal energy, and critical minerals production. With research sites in Albany, Oregon; Morgantown, West Virginia; and Pittsburgh, Pennsylvania, NETL operates as one laboratory to apply its expertise in subsurface materials and processes, materials engineering, energy conversion, systems analysis, computational science, and program deployment to implement DOE programs across the nation and advance energy technologies. The Lab further strengthens its impact by engaging with industry, academia, and other stakeholders through four strategically located Centers of Excellence: Coal, Critical Minerals and Advanced Alloys, Oil & Gas, and Geothermal. Through its collaborations and world-class research, NETL is strengthening national energy security and contributing to an America that leads the world with affordable, reliable, and secure energy to fuel human prosperity. NETL supports the Genesis Mission through leadership and technical expertise. NETL personnel serve on the Data Leadership Pillar's expert advisory team and have been instrumental in fostering interagency collaboration and establishing partnership agreements with Genesis Mission leadership. As part of the Modeling Consortium, NETL co-leads the CM2US seed modeling team, bringing key critical minerals and materials expertise to the resource discovery, materials discovery, and supply resiliency foundation modeling effort. NETL also actively informs and supports the Integrated Partnership Provisioning Framework, ensuring robust federal partnership agreements, and leads the data governance task team under the Database Services effort, developing recommendations for open data policies, AI-readiness, data provenance, and security strategies. NETL's Energy Data eXchange (EDX) is a key infrastructure partner for Genesis Mission's American Science Cloud (AmSC) platform, integrating millions of public-facing data resources.

More information coming soon.

As the largest science and energy laboratory for the U.S. Department of Energy (DOE), Oak Ridge National Laboratory (ORNL) is leveraging AI across its scientific portfolio to strengthen the nation’s energy, security, and competitiveness.

ORNL researchers are embedding AI directly into scientific workflows, developing explainable methods that deliver near-real-time insight in areas such as quantum materials, nuclear energy, and cybersecurity. This work moves beyond traditional data analysis toward autonomous science, where AI helps guide experiments, modeling, and decision-making to reduce time to solution. In parallel, ORNL is developing secure-by-design architectures with built-in guardrails to help protect against misuse and adversarial threats.

To enable the Genesis Mission, ORNL is charting new pathways for AI-driven science through the American Science Cloud, a secure, connected, science-optimized platform linking DOE computing and experimental facilities.

These advances are possible through ORNL’s exascale computing resources. In addition to the Frontier exascale system at ORNL, two new systems—Lux and Discovery—will advance the Genesis Mission. Planned for 2026, Lux will expand DOE’s near-term AI capacity and accelerate progress on Genesis priorities including fusion, fission, materials, quantum, advanced manufacturing, and the grid. Expected in 2028, Discovery will advance high-performance modeling and simulation integrated with AI, while paving the way for the convergence of high-performance computing (HPC), AI, and quantum computing.

By advancing the Genesis Mission, ORNL is helping ensure AI remains a secure, reliable partner in discovery and that the United States continues to lead scientifically and economically.

Pacific Northwest National Laboratory (PNNL) is a key partner in the Genesis Mission, the Department of Energy’s integrated ecosystem to accelerate discovery and strengthen U.S. leadership in AI-powered science.

Drawing on its deep expertise in the design and application of AI, novel computing paradigms, and fundamental science, PNNL is creating AI solutions to aid autonomous discovery science in chemistry, materials, and biology, speed environmental permitting, and ensure reliable, secure energy grids. Together, these efforts and more make PNNL a transformational AI engine advancing the nation’s scientific, energy, and national security missions.

A U.S. Department of Energy National Laboratory managed by Princeton University, the Princeton Plasma Physics Laboratory (PPPL) is tackling the world’s toughest science and technology challenges using plasma, the fourth state of matter. The Lab conducts essential research across a full range of plasma applications, whether it’s developing fusion as a potentially limitless power source, creating the next generation of materials for microelectronics and quantum sensors and devices, or electrifying chemical and materials manufacturing processes.

PPPL’s research brings together theory, computation, and experimentation to advance plasma sciences and the development of practical fusion energy. Across its departments, PPPL integrates foundational plasma physics, high-fidelity simulation, AI, and large-scale experimental research to understand and control complex, multi-scale plasma behavior. This work spans predictive modeling of plasma stability, the development of advanced computational frameworks and physics-informed AI, and experimental validation across a global network of tokamak facilities. By combining data from world-leading experiments with advanced modeling and machine learning, PPPL is building a data-rich laboratory that accelerates scientific discovery, supports reactor design, and drives progress toward commercially viable fusion energy.

We’re a proud partner of the Genesis Mission, using our deep expertise in AI, computational modeling, and digital engineering to advance U.S. competitiveness and national security. Our involvement with the Genesis Mission is primarily focused on using AI for fusion — speeding the development of a fusion pilot plant. We’re developing a new computational infrastructure called STELLAR AI to speed up computer simulations, a digital twin or virtual model of the Lab’s primary fusion experiment: the National Spherical Torus Experiment-Upgrade (NSTX-U), and developing critical surrogate and foundation models for fusion systems. PPPL also brings together experts from around the world to explore how AI is accelerating the path to commercial fusion power with the AI4Fusion Colloquium, an online lecture series.

Sandia National Laboratories is a federally funded research and development center that supports the national security mission of the United States through science, engineering, and technology development. Within the Genesis Mission Consortium, Sandia’s role is centered on applying artificial intelligence, advanced computing, and digital engineering capabilities to high-consequence national security problems, particularly those relevant to the National Nuclear Security Administration.

Sandia brings a combination of mission depth and technical breadth that is unique to Genesis. This includes expertise in weapons engineering, digital engineering, high-performance computing, modeling and simulation, advanced manufacturing, data systems, and secure mission execution. Sandia also has strong experience integrating research and development capabilities into operational mission environments, which is essential for translating AI concepts into usable tools and workflows.

In the Genesis Mission, Sandia is contributing in both platform development and mission application. On the platform side, Sandia supports the development of infrastructure, models, and data capabilities needed to enable secure, mission-relevant AI use across the complex. On the application side, Sandia is helping define and execute high-impact use cases and Mission Science and Technology Challenges, including areas related to design and production integration, engineering workflow acceleration, manufacturing, data exploitation, and safety-basis modernization.

Sandia’s contribution to the Consortium is not limited to technical development. The laboratory also plays an important coordinating role by helping connect mission users, platform developers, and partner institutions across the tri-lab and DOE/NNSA environment. Through this combination of mission understanding, technical execution, and systems integration, Sandia is positioned to help ensure the Genesis Mission delivers practical, scalable capability in support of national security and broader government needs.

Savannah River National Laboratory brings decades of expertise in nuclear materials management, environmental cleanup, national security, and advanced chemical processing to the Department of Energy’s Genesis Mission. SRNL researchers and their partners are committed to driving the development of AI models to accelerate research and development in key national mission areas.

As one of the 17 national laboratories mobilized for this historic endeavor, SRNL harnesses the power of artificial intelligence to advance multidisciplinary applied sciences that support critical DOE and NNSA missions. This includes advancements in nuclear and critical materials, tritium, and isotope sciences vital for developing weapons production technology and securing the nation. Our work directly enhances national security, environmental stewardship, and energy resilience, ultimately strengthening America's leadership and competitiveness.

SRNL’s new Advanced Manufacturing Collaborative is a state-of-the-art facility among the lab’s myriad capabilities available to support Genesis Mission success. The AMC will build partnerships with government, academia and industry at local, regional and national levels. Working together with these sectors, the AMC will serve as an innovation incubator that will commercialize solutions to real-world challenges.

The Genesis Mission exemplifies the spirit of discovery and collaboration that defines SRNL. Together, we are advancing the solutions that will define the next era of innovation.

Learn more about SRNL's featured initiatives for the Genesis Mission at https://www.srnl.gov/srnl-genesis-mission/.

SLAC National Accelerator Laboratory, operated by Stanford University for the DOE Office of Science, explores how the universe works at the biggest, smallest and fastest scales and invents powerful tools used by scientists around the globe. Our research helps solve real-world problems and advances the interests of the nation.

SLAC’s premier facilities produce vast and uniquely varied scientific data sets that illuminate our world from the grand scale of the cosmos to the smallest scales of the motions of electrons. These data – along with the SLAC-Stanford ecosystem's expertise in algorithm development and its world-leading domain scientists – will fuel the AI revolution in science.

SLAC’s contributions to the Genesis Mission bring together advanced computing infrastructure, AI innovation, and data from world-leading scientific facilities to power the next generation of discovery. These coordinated efforts span fields from cosmology and particle physics to materials, catalysis, and critical mineral supply chains, and from accelerator control systems to time-resolved multi-modal data acquisition, strengthening U.S. leadership in AI-enabled science and technology.

More information coming soon.

Kansas City National Security Campus (KCNSC) is one of eight sites that comprise the National Nuclear Security Administration (NNSA). Our primary focus is manufacturing 80 percent of non-nuclear components that go into the nuclear stockpile. Along with safeguarding the country’s nuclear weapons, the KCNSC team leads other missions for the Department of Energy including providing products and services that support proliferation deterrence, supply chain management, and responsiveness to global threats.

The Nevada National Security Sites (NNSS), part of the U.S. Department of Energy’s (DOE) National Nuclear Security Administration (NNSA), is an enterprise of special-purpose, multi-mission, high-hazard experimentation facilities delivering technical and service solutions in partnership with the National Laboratories. Our collaborative work supports the government’s most important national security missions.

As the cornerstone of the nation’s Nuclear Security Enterprise, Pantex applies unique capabilities to ensure the effectiveness of the U.S. nuclear stockpile in support of the Nation’s nuclear deterrent. We accomplish this through executing nuclear explosive assembly and disassembly, special nuclear material testing and evaluations, and manufacturing and assessing high explosives at our historic site.

The Pantex mission has grown over the decades as other facilities closed and responsibilities for life-extension, surveillance, assembly and high explosives operations were moved to the site.

Since 1975, Pantex has been the nation’s primary assembly, disassembly, retrofit, and life-extension center for nuclear weapons. The last new nuclear weapon was completed in 1991. Since then, Pantex has safely dismantled thousands of weapons retired from the stockpile by the military and placed the resulting plutonium pits in interim storage.

Operations at Pantex are primarily conducted on 2,000 acres of the 18,000-acre site. Pantex has approximately 650 buildings, including specialized facilities in which maintenance, modification, disassembly, and assembly operations are conducted. The Pantex Plant maintains its own water-treatment, sewage, and steam-generating plants. Five wind turbines, each over 400 feet tall, generate enough power to support more than 60 percent of the Pantex Plant’s annual energy. The strength of Pantex lies in the dedication and patriotic commitment of its more than 4,700 full-time personnel.

As a National Nuclear Security Administration (NNSA) stewarded plant, dedicated to maintaining the highest possible safety and security standards, the Savannah River Site (SRS) is responsible for supporting our nation’s nuclear defense through its Savannah River Tritium Enterprise and its pit production mission; preventing nuclear weapon proliferation; environmental stewardship and cleanup; waste management; and disposition of nuclear materials. SRS is exploring tools, such as AI, to aid in innovation across its missions by helping to accelerate and de-risk work. Our vision is to use these tools to enhance efficiency, ensure safety, and unlock new operational capabilities.

The Y-12 National Security Complex is a premier manufacturing facility dedicated to making our nation and the world a safer place and plays a vital role in the Department of Energy’s Nuclear Security Enterprise.

Y-12 helps ensure a safe and effective U.S. nuclear weapons deterrent. We also retrieve and store nuclear materials, fuel the nation’s naval reactors, and perform complementary work for other government and private-sector entities.

Since 1943, Y-12 has played a key role in strengthening our country’s national security and reducing the global threat from weapons of mass destruction.
Y-12 has evolved to become the complex the nation looks to for support in protecting America's future, developing innovative solutions in manufacturing technologies, prototyping, safeguards and security, technical computing and environmental stewardship.